祝钦泷

发布者:体育外围官网发布时间:2018-08-09浏览次数:2347


      博士、青年教授  性别: 男

      所属单位:遗传学系

      Email:zhuql@scau.edu.cn

  



个人简介

       农学博士, 青年教授。2007年毕业于西南大学园艺学(花卉分子育种)专业,获农学博士学位。现就职于体育外围官网,亚热带农业生物资源保护与利用国家重点实验室。主要从事植物基因工程技术系统(多基因载体系统和基因组编辑CRISPR/Cas9系统)的开发及其植物代谢工程与合成生物学应用(水稻、园艺作物的类黄酮、花青素、类胡萝卜素生物合成与代谢调控;水稻营养物质强化的多基因代谢工程应用)。开发了第二代多基因载体系统TGSII,  培育出全球首个胚乳富含花青素的“紫晶米”和首个胚乳合成虾青素的“赤晶米”。 作为第一导师指导学生获得2016 iGEM(国际基因工程机器)大赛全球金奖与4个单项奖(包括全球总成绩第三“Second Runner-Up”,以及首个最佳植物合成生物学奖“Best Plant Synthetic Biology”等单项奖)。


工作经历

2019.10-至今:体育外围官网/亚热带农业生物资源保护与利用国家重点实验室,青年教授
2016.12-2019.9:体育外围官网/亚热带农业生物资源保护与利用国家重点实验室,副研究员
2017.12-2018.11 :美国康奈尔大学(Cornell University)/Robert W. Holley Center, Plant Science, 客座副教授(Visiting Associate Professor)
2011.07-2016.11  :体育外围投注平台生命科的学学院,助理研究员
2007.08-2011.06:体育外围官网,生物学博士后流动站,博士后


学习经历

2004-09至2007-06,西南大学, 园艺学(花卉分子育种)专业,农学博士;
2001-09至2004-07,西南农业大学(现西南大学),细胞生物学专业,理学硕士;
1997-09至2001-06,四川畜牧兽医学院(现西南大学荣昌校区),动物科学专业,农学学士;


主持的科研项目

8. 国家自然科学基金面上项目(31971915),2020.1-2023.12;
7.转基因专项“转基因新技术新方法”子课题(2016ZX08010001-008),2019.1-2020.12;
6.国家自然科学基金面上项目(31771740),2018.1-2021.12;
5.广东省公益研究与能力建设项目(2016A020210084),2016.1-2018.12;
4.国家自然科学基金青年基金(31000698),2011.1-2013.12;
3.广东省自然科学基金(10451064201005422),2010.10-2012.10;
2.国家“863”计划课题“高效、安全转基因技术的创建”子课题(2007AA10Z184)2007.9-2010.8;
1.博士后科学基金(20070420787),2007.9-2010.12;


发表的主要研究论文

2019:

26. Zeng D, Li X, Huang J, Li Y, Cai S, Yu W, Li Y, Huang Y, Xie X, Gong Q, Tan J, Zheng Z, Guo M, Liu Y-G*, Zhu Q*. Engineered Cas9 variant tools expand targeting scope of genome and base editing in rice. Plant Biotechnology Journal, 2019, doi: 10.1111/pbi.13293.(IF2018=6.84)

25. Tan J, Gong Q, Yu S, Hou Y, Zeng D, Zhu Q*, Liu Y-G*.  A modified high-efficiency thermal asymmetric interlaced PCR method for amplifying long unknown flanking sequences. Journal of Genetics and Genomics, 2019,46(7):363-366. (IF2018=4.65)

24. Ma K, Han J, Hao Y, Yang Z, Chen J, Liu Y-G, Zhu Q*, Chen L*. An effective strategy to establish a male sterility mutant mini-library by CRISPR/Cas9 knockout of anther-specific genes in rice. Journal of Genetics and Genomics, 2019, 46 (5): 273-275.(IF2018=4.65)

2018:

23.Zhu Q, Zeng D, Yu S, Cui C, Li J, Li H, Chen J, Zhang R, Zhao X, Chen L, Liu Y-G*. From Golden Rice to aSTARice: Bioengineering Astaxanthin Biosynthesis in Rice Endosperm.Molecular plant, 2018,11(12): 1440-1448.(“赤晶米”,封面文章).(IF2018=10.812)

22. Xie Y, Zhang Y, Han J, Luo J, Li G, Huang J, Wu H, Tian Q, Zhu Q, Chen Y, Kawano Y, Liu Y-Guang, Chen L*. The Intronic cis Element SE1 Recruits trans-Acting Repressor Complexes to Repress the Expression of ELONGATED UPPERMOST INTERNODE1 in Rice. Molecular plant, 2018, 11(5):720-735.(IF2018=10.812)

2017:

21. Shen R, Wang L, Liu X, Wu J, Jin W, Zhao X, Xie X, Zhu Q, Tang H, Li Q, Chen L, Liu Y-G*. Genomic structural variation-mediated allelic suppression causes hybrid male sterility in rice. Nature Communications, 2017, 8(1): 1310. (IF2017=12.353)

20. Li X, Xie Y, Zhu Q, Liu Y-G*. Targeted Genome Editing in Genes and Cis-Regulatory Regions Improves Qualitative and Quantitative Traits in Crops. Molecular Plant, 2017, 10 (11):1368-1370.(IF2017=9.326)

19. Zhu Q, Yu S, Zeng D, Liu H, Wang H, Yang Z, Xie X, Shen R, Tan J, Li H, Zhao X, Zhang Q, Chen Y, Guo J, Chen L, Liu Y-G*. Development of “Purple Endosperm Rice” by engineering anthocyanin biosynthesis in the endosperm with a high-efficiency transgene stacking system. Molecular Plant, 2017, 10 (7): 918-929.(“紫晶米”,封面文章, Best of Molecular Plant 2017).(IF2017=9.326)

18. Zhong G, Zhu Q, Li Y, Liu Y, Wang H*. Once for All: A Novel Robust System for Co-expression of Multiple Chimeric Fluorescent Fusion Proteins in Plants. Front. Plant Sci. 2017, 8:1071. doi: 10.3389/fpls.2017.01071.(IF2017=3.678)

17. Xie X, Ma X, Zhu Q, Zeng D, Li G, and Liu Y-G. CRISPR-GE: A Convenient Software Toolkit for CRISPR-Based Genome Editing. Molecular Plant, 2017, 10(9):1246-1249.(IF2017=9.326)

16. Lu K, Peng L, Zhang C, Lu J, Yang B, Xiao Z, Liang Y, Xu X, Qu C, Zhang K, Liu L, Zhu Q, Fu M, Yuan X and Li J*. Genome-Wide Association and Transcriptome Analyses Reveal Candidate Genes Underlying Yield-determining Traits in Brassica napus. Front. Plant Sci. 2017, 8: 206. doi: 10.3389/fpls.2017.00206.(IF2017=3.678)

15. Chen W, Zhu Q, Liu Y and Zhang Q*. Chromatin Remodeling and Plant Immunity. Advances in Protein Chemistry and Structural Biology. 2017, 106: 243 – 260. (IF2017=2.439)

2016:

14. Chen W, Zeng D, Shen R, Ma X, Zhang Q, Chen L, Liu Y-G*, Zhu Q*. Rapid in vitro splicing of coding sequences from genomic DNA by isothermal recombination reaction-based PCR. Biotechnology & Biotechnological Equipment, 2016, 30(5): 864-868.(IF2016=1.059)

13. Ma X, Zhu Q, Chen Y, Liu Y-G*.CRISPR/Cas9 platforms for genome editing in plants: developments and applications.Molecular Plant, 2016, 9 (7): 961-974.(Best of Molecular Plant 2016ESI高被引论文).(IF2016=8.827)

2015:

12.Zhu Q*, Sui S, Lei X, Yang Z, Lu K, Liu G, Liu Y-G, Li M*.Ectopic Expression of the Coleus R2R3 MYB-Type Proanthocyanidin Regulator Gene SsMYB3 Alters the Flower Color in Transgenic Tobacco. PLoS One2015, 10 (10): e0139392.(IF2017=3.057)

11. Zhu Q*, Xie X, Lin H, Sui S, Shen R, Yang Z, Lu K, Li M, Liu Y-G*. Isolation and Functional Characterization of a Phenylalanine Ammonia-Lyase Gene (SsPAL1) from Coleus (Solenostemon scutellarioides (L.) Codd). Molecules, 2015, 20(9): 16833-16851.(IF2015=2.465)

10. Ma X, Zhang Q, Zhu Q, Liu W, Chen Y, Qiu R, Wang B, Yang Z, Li H, Lin Y, Xie Y, Shen R, Chen S, Wang Z, Chen Y, Guo J, Chen L, Zhao X, Dong Z, and Liu Y-G*.A robust CRISPR/Cas9 system for convenient high-efficiency multiplex genome editing in monocot and dicot plants. Molecular Plant, 2015, 8(8): 1274-1284 (ESI 高引论文).(IF2015=7.142)

9. Ma X, Chen L, Zhu Q, Chen Y, Liu Y-G*. Rapid decoding of sequence-specific nuclease-induced heterozygous and biallelic mutations by direct sequencing of PCR products. Molecular Plant, 2015, 8(8): 1285-1287.

8. Wang C, Zhang X, Fan Y, Gao Y, Zhu Q, Zheng C, Qin T, Li Y, Che J, Zhang M, Yang B, Liu Y-G, Zhao K*.XA23 is an executor R protein and confers broad-spectrum disease resistance in rice. Molecular Plant, 2015, 8(2): 290-302. (ESI高被引论文(IF2015=7.142)

2014 and before:

7. Zhu Q*, Yang Z, Zhang Q, Chen L, Liu Y-G*. Robust multi-type plasmid modification based on isothermal in vitro recombination. Gene2014548(1): 39-42. (IF2014=2.138)

6. Zhu Q*, Xie X, Zhang J, Xiang G, Li Y , Wu H. In Silico Analysis of a MRP Transporter Gene Reveals Its Possible Role in Anthocyanins or Flavonoids Transport in Oryze sativa. American Journal of Plant Sciences, 2013, 4 (3):555-560.

5. Jiang Y, Xie M, Zhu Q, Ma X, Li X, Liu Y, Zhang Q*. One-step cloning of intron-containing hairpin RNA constructs for RNA interference via isothermal in vitro recombination system. Planta, 2013, 238(2): 325-330.(IF2014=3.347)

4. Sui S, Luo J, Ma J, Zhu Q, Lei X, Li M*. Generation and Analysis of Expressed Sequence Tags from Chimonanthus praecox (wintersweet) flower for discovering stress-responsive and floral development related genes. Comparative and Functional Genomics, 2012: 134596. doi: 10.1155/2012/ 134596 .

3. Zhu QL, Guo TY, Sui SZ, Liu GD, Lei XH, Luo LL, Li MY*. Molecular cloning and characterization of a novel isoflavone reductase-like gene (FcIRL) from high flavonoids- producing callus of Fagopyrum cymosum. Acta Pharmaceutica Sinica, 2009, 44(7): 809-819.

2Zhu QL, Li MY*, Liu GD, Li YD, Sui SZ, Guo TY. Molecular characterization and functional prediction of a novel leaf SAG encoding a CBS-domain-containing protein from Coleus blumei. Chinese Journal of Biochemistry and Molecular Biology, 2007, 23 (4):249-255. (封面文章)

1Guo Y, Zhu Q, Zheng S, Li M*. Cloning of a MADS Box Gene (GhMADS3) from Cotton and Analysis of its Homeotic Role in Transgenic Tobacco. Journal of Genetics and Genomics2007, 34(6): 527-535.


学术兼职

1.中国生物化学与分子生物学学会(CSBMB)会员;
2.中国植物生理与植物分子生物学学会(CSPB)会员;
3.国际学术期刊Molecular Plant, Planta, Plant Biology, Current Microbiology,Phytochemistry Letters,Plant Cell, Tissue and Organ Culture等的特邀审稿人;


荣誉和奖励

8. 2019年第十三届中国生物工程学会年会暨全国生物技术大会,青年优秀论文特等奖;
7. 2019年第二届分子植物育种大会优秀墙报奖;
6. 2019年中国生物工程学会第四届青年科技论坛优秀墙报奖;
5. 2018年第四届“药食同源与植物代谢国际研讨会”优秀墙报(二等奖);
4. 2017年第十届大北农科技奖基因工程奖(第6/12);
3. 2017 the Best POSTER AWARD, the 4th ICPM (International Conference on Plant Metabolism), CSPB(Chinese Society for Plant Biology);
2. 2009年第六届中国科协期刊优秀学术论文(三等奖); 
1. 2007年郑集-张昌颖青年优秀论文奖,CSBMB (The Chinese Society of Biochemistry and Molecular Biology);


发明专利

6.一种水稻育性基因SAW1及其应用,专利申请号:20191192671.1;
5.一种花药特异表达启动子PV4及其应用,专利申请号:201710369461.X;
4.一种多基因组装载体系统及其多基因组装方法,专利申请号:201710384197.7;
3.一种在作物种子胚乳合成花青素的转基因育种方法,专利申请号:201710368951.8;
2.一种在作物种子胚乳生产虾青素的转基因育种方法,专利申请号:201610283794.6;
1.一种水稻雄性育性可控系的构建方法及其在杂交育种的应用,专利号:ZL201210339978.1;


教学成果

9. 2019年体育外围投注平台教学成果二等奖;
8. 指导2015级本科生黄银频等获得国家级大学生创新创业训练项目资助1项(201710564238); 
7.指导本科生李嘉敏等组成的SCAU-China队伍,参加2016 iGEM(国际基因工程大赛)竞赛,荣获全球总赛金奖,总决赛季军(Second Runner-Up)、“最佳新应用项目奖(Best New Application Project)、“最佳教育和公众参与奖(Best Education and    Public Engagement )” 和“植物合成生物学最佳成就奖(Best Achievement in Plant Synthetic Biology)”4个单项奖,是成绩最好的中国高校队伍;
6. 指导2014级本科生陈君宇等获2016年广东省大学生生化技能大赛三等奖;
5.指导2013级本科生崔超军等在中文核心期刊《西北植物学报》和《重庆师范大学学报-自然科学版》分别发表学术论文;
4. 指导2013级本科生崔超军等获得国家级大学生创新创业训练项目资助1项(201610564006);
3. 指导2013级本科生王建博等获得校级大学生创新创业训练项目资助1项(201610564166);
2. 指导2011级本科生陈文轩等在SCI杂志Biotechnology & Biotechnological Equipment上发表学术论文;
1. 指导2011级本科生陈文轩等获得校级大学生创新创业训练项目资助1项(SCX13111);